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Target
Matrix metalloproteinase-16
Ligand
BDBM50361599
Substrate
n/a
Meas. Tech.
ChEMBL_799129 (CHEMBL1942113)
IC50
1100±n/a nM
Citation
 Marques, SM; Tuccinardi, T; Nuti, E; Santamaria, S; André, V; Rossello, A; Martinelli, A; Santos, MA Novel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases. J Med Chem 54:8289-98 (2011) [PubMed]  Article 
Target
Name:
Matrix metalloproteinase-16
Synonyms:
C8orf57 | MMP-16 | MMP-X2 | MMP16 | MMP16_HUMAN | MMPX2 | MT-MMP 3 | MT3-MMP | MT3MMP | MTMMP3 | Matrix metalloproteinase 16 | Matrix metalloproteinase-16 | Membrane-type matrix metalloproteinase 3 | Membrane-type-3 matrix metalloproteinase
Type:
PROTEIN
Mol. Mass.:
69536.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_799129
Residue:
607
Sequence:
MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV
  
Inhibitor
Name:
BDBM50361599
Synonyms:
CHEMBL1939844
Type:
Small organic molecule
Emp. Form.:
C14H18N2O6S
Mol. Mass.:
342.368
SMILES:
COc1ccc(cc1)S(=O)(=O)N1CC(=O)N(O)C(=O)[C@H]1C(C)C |r|
Structure:
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