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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50362372
Substrate
n/a
Meas. Tech.
ChEMBL_797803 (CHEMBL1944259)
IC50
4500±n/a nM
Citation
 Melancon, BJ; Lamers, AP; Bridges, TM; Sulikowski, GA; Utley, TJ; Sheffler, DJ; Noetzel, MJ; Morrison, RD; Scott Daniels, J; Niswender, CM; Jones, CK; Conn, PJ; Lindsley, CW; Wood, MR Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012. Bioorg Med Chem Lett 22:1044-8 (2012) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50362372
Synonyms:
CHEMBL1939957
Type:
Small organic molecule
Emp. Form.:
C18H19ClN6O3S2
Mol. Mass.:
466.965
SMILES:
Clc1ccnc(c1)N1CCN(CC1)C(=O)CCNS(=O)(=O)c1cccc2nsnc12
Structure:
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