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Target
Plasmepsin II
Ligand
BDBM50362538
Substrate
n/a
Meas. Tech.
ChEMBL_797829 (CHEMBL1942415)
IC50
34000±n/a nM
Citation
 Saify, ZS; Azim, MK; Ahmad, W; Nisa, M; Goldberg, DE; Hussain, SA; Akhtar, S; Akram, A; Arayne, A; Oksman, A; Khan, IA New benzimidazole derivatives as antiplasmodial agents and plasmepsin inhibitors: synthesis and analysis of structure-activity relationships. Bioorg Med Chem Lett 22:1282-6 (2012) [PubMed]  Article 
Target
Name:
Plasmepsin II
Synonyms:
Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II
Type:
Enzyme
Mol. Mass.:
51482.09
Organism:
Plasmodium falciparum
Description:
P46925
Residue:
453
Sequence:
MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYENVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKTNYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
  
Inhibitor
Name:
BDBM50362538
Synonyms:
CHEMBL1941015
Type:
Small organic molecule
Emp. Form.:
C22H19N3O3
Mol. Mass.:
373.4046
SMILES:
COc1ccc(OC)c(c1)C(=O)Cn1c(nc2ccccc12)-c1ccccn1
Structure:
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