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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM50364776
Substrate
n/a
Meas. Tech.
ChEMBL_803132 (CHEMBL1954568)
IC50
69±n/a nM
Citation
 Pastor, J; Oyarzabal, J; Saluste, G; Alvarez, RM; Rivero, V; Ramos, F; Cendón, E; Blanco-Aparicio, C; Ajenjo, N; Cebriá, A; Albarrán, MI; Cebrián, D; Corrionero, A; Fominaya, J; Montoya, G; Mazzorana, M Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors. Bioorg Med Chem Lett 22:1591-7 (2012) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM50364776
Synonyms:
CHEMBL1952141 | CHEMBL1952329
Type:
Small organic molecule
Emp. Form.:
C20H22F3N5O
Mol. Mass.:
405.4168
SMILES:
CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1
Structure:
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