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Target
Mitogen-activated protein kinase 14
Ligand
BDBM69530
Substrate
n/a
Meas. Tech.
ChEMBL_806241 (CHEMBL1958782)
IC50
720±n/a nM
Citation
 Choi, H; Park, HJ; Shin, JC; Ko, HS; Lee, JK; Lee, S; Park, H; Hong, S Structure-based virtual screening approach to the discovery of p38 MAP kinase inhibitors. Bioorg Med Chem Lett 22:2195-9 (2012) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM69530
Synonyms:
(4-Amino-2-phenylamino-thiazol-5-yl)-phenyl-methanone | (4-amino-2-anilino-1,3-thiazol-5-yl)-phenylmethanone | (4-amino-2-anilino-5-thiazolyl)-phenylmethanone | (4-amino-2-anilino-thiazol-5-yl)-phenyl-methanone | (4-azanyl-2-phenylazanyl-1,3-thiazol-5-yl)-phenyl-methanone | MLS000767184 | SMR000429508 | cid_936046
Type:
Small organic molecule
Emp. Form.:
C16H13N3OS
Mol. Mass.:
295.359
SMILES:
Nc1nc(Nc2ccccc2)sc1C(=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: