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Target
D(2) dopamine receptor
Ligand
BDBM50281609
Substrate
n/a
Meas. Tech.
ChEMBL_61436 (CHEMBL671409)
IC50
128±n/a nM
Citation
 Jaen, JC; Caprathe, BW; Wise, LD; Meltzer, LT; Pugsley, TA; Huffner, TG Synthesis and pharmacological evaluation of the enantiomers of the dopamine autoreceptor agonist PD 135385 Bioorg Med Chem Lett 3:639-644 (1993)    Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50281609
Synonyms:
1-Pyridin-2-yl-4-[2-(4-pyridin-2-yl-cyclohex-3-enyl)-ethyl]-piperazine | CHEMBL346075 | PD-135540
Type:
Small organic molecule
Emp. Form.:
C22H28N4
Mol. Mass.:
348.4845
SMILES:
C(CN1CCN(CC1)c1ccccn1)C1CCC(=CC1)c1ccccn1 |c:19|
Structure:
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