Reaction Details Report a problem with these data
Target
Kynureninase
Ligand
BDBM50288254
Substrate
n/a
Meas. Tech.
ChEBML_91720
Ki
23400±n/a nM
Citation
 Ross, FC; Botting, NP; Leeson, PD Synthesis of phosphinic acid transition state analogues for the reaction catalysed by kynureninase Bioorg Med Chem Lett 6:2643-2646 (1996)    Article 
Target
Name:
Kynureninase
Synonyms:
KYNU | KYNU_HUMAN | L-kynurenine hydrolase
Type:
PROTEIN
Mol. Mass.:
52356.52
Organism:
Homo sapiens (Human)
Description:
ChEMBL_91729
Residue:
465
Sequence:
MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKPALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEKRGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN
  
Inhibitor
Name:
BDBM50288254
Synonyms:
2-ammonio-4-oxo-4-phenyl-(2S)-butanoate | CHEMBL315803
Type:
Small organic molecule
Emp. Form.:
C10H11NO3
Mol. Mass.:
193.1992
SMILES:
[NH3+][C@@H](CC(=O)c1ccccc1)C([O-])=O
Structure:
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