Reaction Details Report a problem with these data
Target
Kynureninase
Ligand
BDBM50288258
Substrate
n/a
Meas. Tech.
ChEBML_91720
Ki
880000±n/a nM
Citation
 Ross, FC; Botting, NP; Leeson, PD Synthesis of phosphinic acid transition state analogues for the reaction catalysed by kynureninase Bioorg Med Chem Lett 6:2643-2646 (1996)    Article 
Target
Name:
Kynureninase
Synonyms:
KYNU | KYNU_HUMAN | L-kynurenine hydrolase
Type:
PROTEIN
Mol. Mass.:
52356.52
Organism:
Homo sapiens (Human)
Description:
ChEMBL_91729
Residue:
465
Sequence:
MEPSSLELPADTVQRIAAELKCHPTDERVALHLDEEDKLRHFRECFYIPKIQDLPPVDLSLVNKDENAIYFLGNSLGLQPKMVKTYLEEELDKWAKIAAYGHEVGKRPWITGDESIVGLMKDIVGANEKEIALMNALTVNLHLLMLSFFKPTPKRYKILLEAKAFPSDHYAIESQLQLHGLNIEESMRMIKPREGEETLRIEDILEVIEKEGDSIAVILFSGVHFYTGQHFNIPAITKAGQAKGCYVGFDLAHAVGNVELYLHDWGVDFACWCSYKYLNAGAGGIAGAFIHEKHAHTIKPALVGWFGHELSTRFKMDNKLQLIPGVCGFRISNPPILLVCSLHASLEIFKQATMKALRKKSVLLTGYLEYLIKHNYGKDKAATKKPVVNIITPSHVEERGCQLTITFSVPNKDVFQELEKRGVVCDKRNPNGIRVAPVPLYNSFHDVYKFTNLLTSILDSAETKN
  
Inhibitor
Name:
BDBM50288258
Synonyms:
(R)-2-Benzyloxycarbonylamino-3-(methoxy-phenyl-phosphinoyl)-propionic acid | CHEMBL85072
Type:
Small organic molecule
Emp. Form.:
C18H20NO6P
Mol. Mass.:
377.3283
SMILES:
COP(=O)(C[C@H](NC(=O)OCc1ccccc1)C(O)=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: