Reaction Details Report a problem with these data
Target
Substance-K receptor
Ligand
BDBM50366377
Substrate
n/a
Meas. Tech.
ChEBML_142711
IC50
0.079000±n/a nM
Citation
 Horwell, DC; Naylor, D; Willems, HM 2,3-Substituted 2-azanorbornanes as polar -turn mimetics Bioorg Med Chem Lett 7:31-36 (1997)    Article 
Target
Name:
Substance-K receptor
Synonyms:
NK2R_MESAU | Neurokinin 2 receptor | Neurokinin NK2 | TAC2R | TACR2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43436.75
Organism:
HAMSTER
Description:
P51144
Residue:
384
Sequence:
MGGRAIVTDTNIFSGLESNTTGVTAFSMPAWQLALWATAYLGLVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPITKATIAGIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKMLLLYHLVVFVLVYFLPLVVMFVAYSVIGLTLWKRAVPRHQAHGANLRHLHAKKKFVKAMVLVVLTFAICWLPYHLYFILGSFQKDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTRTPSLSRRVNRCHTKETLFMTADMTHSEATNGQVGSPQDVEPAAP
  
Inhibitor
Name:
BDBM50366377
Synonyms:
CHEMBL334721 | MEN-10627
Type:
Small organic molecule
Emp. Form.:
C38H48N8O7S
Mol. Mass.:
760.902
SMILES:
CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2
Structure:
Search PDB for entries with ligand similarity: