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Target
Glutamine--tRNA ligase
Ligand
BDBM50403640
Substrate
n/a
Meas. Tech.
ChEBML_72305
Ki
380000±n/a nM
Citation
 Desjardins, M; Desgagnes, J; Lacoste, L; Yang, F; Morin, M; Lapointe, J; Chenevert, R Synthesis of inhibitors of glutamyl-tRNA synthetase Bioorg Med Chem Lett 7:2363-2366 (1997)    Article 
Target
Name:
Glutamine--tRNA ligase
Synonyms:
Glutaminyl-tRNA synthetase | QARS | QARS1 | SYQ_HUMAN
Type:
PROTEIN
Mol. Mass.:
87806.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_72305
Residue:
775
Sequence:
MAALDSLSLFTSLGLSEQKARETLKNSALSAQLREAATQAQQTLGSTIDKATGILLYGLASRLRDTRRLSFLVSYIASKKIHTEPQLSAALEYVRSHPLDPIDTVDFERECGVGVIVTPEQIEEAVEAAINRHRPQLLVERYHFNMGLLMGEARAVLKWADGKMIKNEVDMQVLHLLGPKLEADLEKKFKVAKARLEETDRRTAKDVVENGETADQTLSLMEQLRGEALKFHKPGENYKTPGYVVTPHTMNLLKQHLEITGGQVRTRFPPEPNGILHIGHAKAINFNFGYAKANNGICFLRFDDTNPEKEEAKFFTAICDMVAWLGYTPYKVTYASDYFDQLYAWAVELIRRGLAYVCHQRGEELKGHNTLPSPWRDRPMEESLLLFEAMRKGKFSEGEATLRMKLVMEDGKMDPVAYRVKYTPHHRTGDKWCIYPTYDYTHCLCDSIEHITHSLCTKEFQARRSSYFWLCNALDVYCPVQWEYGRLNLHYAVVSKRKILQLVATGAVRDWDDPRLFTLTALRRRGFPPEAINNFCARVGVTVAQTTMEPHLLEACVRDVLNDTAPRAMAVLESLRVIITNFPAAKSLDIQVPNFPADETKGFHQVPFAPIVFIERTDFKEEPEPGFKRLAWGQPVGLRHTGYVIELQHVVKGPSGCVESLEVTCRRADAGEKPKAFIHWVSQPLMCEVRLYERLFQHKNPEDPTEVPGGFLSDLNLASLHVVDAALVDCSVALAKPFDKFQFERLGYFSVDPDSHQGKLVFNRTVTLKEDPGKV
  
Inhibitor
Name:
BDBM50403640
Synonyms:
CHEMBL2115178
Type:
Small organic molecule
Emp. Form.:
C10H18N2O4
Mol. Mass.:
230.2609
SMILES:
NC(CCC(O)=O)C(=O)OC[C@H]1CCCN1 |r|
Structure:
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