Target
C5a anaphylatoxin chemotactic receptor 1
Ligand
BDBM50290463
Substrate
n/a
Meas. Tech.
ChEBML_41457
IC50
40±n/a nM
Citation
 de Laszlo, SAllen, ELi, BOndeyka, DRivero, RMalkowitz, LMolineaux, CSiciliano, SSpringer, MGreenlee, WMantlo, N A nonpeptidic agonist ligand of the human C5a receptor: Synthesis, binding affinity optimization and functional characterization Bioorg Med Chem Lett 7:213-218 (1997)    Article 
Target
Name:
C5a anaphylatoxin chemotactic receptor 1
Synonyms:
C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88
Type:
Enzyme
Mol. Mass.:
39347.68
Organism:
Homo sapiens (Human)
Description:
P21730
Residue:
350
Sequence:
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
  
Inhibitor
Name:
BDBM50290463
Synonyms:
CHEMBL302063 | N-[3-(1-{1-Cyclohexylmethyl-2-[4-(2,6-dimethyl-phenyl)-piperazin-1-yl]-2-oxo-ethyl}-2,5-dioxo-imidazolidin-4-yl)-propyl]-guanidine
Type:
Small organic molecule
Emp. Form.:
C28H43N7O3
Mol. Mass.:
525.6861
SMILES:
Cc1cccc(C)c1N1CCN(CC1)C(=O)[C@@H](CC1CCCCC1)n1c(O)c(CCCNC(N)=N)[nH]c1=O
Structure:
Search PDB for entries with ligand similarity: