Reaction Details Report a problem with these data
Target
C5a anaphylatoxin chemotactic receptor 1
Ligand
BDBM50290466
Substrate
n/a
Meas. Tech.
ChEMBL_41457 (CHEMBL652978)
IC50
350±n/a nM
Citation
 de Laszlo, S; Allen, E; Li, B; Ondeyka, D; Rivero, R; Malkowitz, L; Molineaux, C; Siciliano, S; Springer, M; Greenlee, W; Mantlo, N A nonpeptidic agonist ligand of the human C5a receptor: Synthesis, binding affinity optimization and functional characterization Bioorg Med Chem Lett 7:213-218 (1997)    Article 
Target
Name:
C5a anaphylatoxin chemotactic receptor 1
Synonyms:
C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88
Type:
Enzyme
Mol. Mass.:
39347.68
Organism:
Homo sapiens (Human)
Description:
P21730
Residue:
350
Sequence:
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
  
Inhibitor
Name:
BDBM50290466
Synonyms:
CHEMBL420736 | N-(3-{1-[1-Cyclohexylmethyl-2-oxo-2-(4-o-tolyl-piperazin-1-yl)-ethyl]-2,5-dioxo-imidazolidin-4-yl}-propyl)-guanidine
Type:
Small organic molecule
Emp. Form.:
C27H41N7O3
Mol. Mass.:
511.6595
SMILES:
Cc1ccccc1N1CCN(CC1)C(=O)[C@@H](CC1CCCCC1)n1c(O)c(CCCNC(N)=N)[nH]c1=O
Structure:
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