Reaction Details Report a problem with these data
Target
C5a anaphylatoxin chemotactic receptor 1
Ligand
BDBM50290469
Substrate
n/a
Meas. Tech.
ChEMBL_41457 (CHEMBL652978)
IC50
300±n/a nM
Citation
 de Laszlo, S; Allen, E; Li, B; Ondeyka, D; Rivero, R; Malkowitz, L; Molineaux, C; Siciliano, S; Springer, M; Greenlee, W; Mantlo, N A nonpeptidic agonist ligand of the human C5a receptor: Synthesis, binding affinity optimization and functional characterization Bioorg Med Chem Lett 7:213-218 (1997)    Article 
Target
Name:
C5a anaphylatoxin chemotactic receptor 1
Synonyms:
C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88
Type:
Enzyme
Mol. Mass.:
39347.68
Organism:
Homo sapiens (Human)
Description:
P21730
Residue:
350
Sequence:
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
  
Inhibitor
Name:
BDBM50290469
Synonyms:
5-[3-amino(imino)methylaminopropyl]-3-[1-cyclohexylmethyl-2-oxo-2-spiro[2,3-dihydro-1H-indene-1,4'-(hexahydropyridine)]-1-yl-(1R)-ethyl]-(5R)-tetrahydro-1H-2,4-imidazoledione | CHEMBL68555
Type:
Small organic molecule
Emp. Form.:
C29H42N6O3
Mol. Mass.:
522.6822
SMILES:
NC(=N)NCCCc1[nH]c(=O)n([C@H](CC2CCCCC2)C(=O)N2CCC3(CCc4ccccc34)CC2)c1O
Structure:
Search PDB for entries with ligand similarity: