Reaction Details Report a problem with these data
Target
C5a anaphylatoxin chemotactic receptor 1
Ligand
BDBM50290480
Substrate
n/a
Meas. Tech.
ChEBML_41457
IC50
1200±n/a nM
Citation
 de Laszlo, S; Allen, E; Li, B; Ondeyka, D; Rivero, R; Malkowitz, L; Molineaux, C; Siciliano, S; Springer, M; Greenlee, W; Mantlo, N A nonpeptidic agonist ligand of the human C5a receptor: Synthesis, binding affinity optimization and functional characterization Bioorg Med Chem Lett 7:213-218 (1997)    Article 
Target
Name:
C5a anaphylatoxin chemotactic receptor 1
Synonyms:
C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88
Type:
Enzyme
Mol. Mass.:
39347.68
Organism:
Homo sapiens (Human)
Description:
P21730
Residue:
350
Sequence:
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
  
Inhibitor
Name:
BDBM50290480
Synonyms:
5-[3-amino(imino)methylaminopropyl]-3-[2-methyl-1-spiro[2,3-dihydro-1H-indene-1,4'-(hexahydropyridine)]-1-ylcarbonyl-(1R)-propyl]-(5R)-tetrahydro-1H-2,4-imidazoledione | CHEMBL420926
Type:
Small organic molecule
Emp. Form.:
C25H36N6O3
Mol. Mass.:
468.5917
SMILES:
CC(C)[C@H](C(=O)N1CCC2(CCc3ccccc23)CC1)n1c(O)c(CCCNC(N)=N)[nH]c1=O
Structure:
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