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Target
Tubulin alpha-1A chain
Ligand
BDBM50072182
Substrate
n/a
Meas. Tech.
ChEMBL_225981 (CHEMBL844178)
IC50
39000±n/a nM
Citation
 Poncet, J; Hortala, L; Busquet, M; Guéritte-Voegelein, F; Thoret, S; Pierré, A; Atassi, G; Jouin, P Synthesis and antiproliferative activity of a cyclic analog of dolastatin 10. Bioorg Med Chem Lett 8:2855-8 (1999) [PubMed]  Article 
Target
Name:
Tubulin alpha-1A chain
Synonyms:
TBA1A_PIG | TUBA1A | Tubulin | Tubulin alpha chain | Tubulin alpha-1A chain
Type:
Protein
Mol. Mass.:
50049.25
Organism:
Sus scrofa (Pig)
Description:
P02550
Residue:
451
Sequence:
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFSVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRAHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYEPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY
  
Inhibitor
Name:
BDBM50072182
Synonyms:
(2S,5S,6R,7S,14R,15S,18S,21S,22R)-2-Benzyl-15-((S)-sec-butyl)-21-dimethylamino-18-isopropyl-6,14-dimethoxy-5,16,22-trimethyl-23-oxa-27-thia-3,11,16,19,28-pentaaza-tricyclo[23.2.1.0*7,11*]octacosa-1(28),25-diene-4,12,17,20,24-pentaone | CHEMBL318667
Type:
Small organic molecule
Emp. Form.:
C42H64N6O8S
Mol. Mass.:
813.058
SMILES:
CC[C@H](C)[C@H]1[C@@H](CC(=O)N2CCC[C@H]2[C@H](OC)[C@H](C)C(=O)N[C@@H](Cc2ccccc2)c2nc(cs2)C(=O)O[C@H](C)[C@H](N(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1C)OC
Structure:
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