Reaction Details Report a problem with these data
Target
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Ligand
BDBM50085484
Substrate
n/a
Meas. Tech.
ChEBML_223410
Ki
305±n/a nM
Citation
 de L Ufret, M; Imperiali, B Probing the extended binding determinants of oligosaccharyl transferase with synthetic inhibitors of asparagine-linked glycosylation. Bioorg Med Chem Lett 10:281-4 (2000) [PubMed]  Article 
Target
Name:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Synonyms:
DDOST | DDOST 48 kDa subunit | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit | KIAA0115 | OST48 | OST48_HUMAN | Oligosaccharyl transferase 48 kDa subunit
Type:
PROTEIN
Mol. Mass.:
50800.18
Organism:
Homo sapiens (Human)
Description:
ChEMBL_223410
Residue:
456
Sequence:
MGYFRCARAGSFGRRRKMEPSTAARAWALFWLLLPLLGAVCASGPRTLVLLDNLNVRETHSLFFRSLKDRGFELTFKTADDPSLSLIKYGEFLYDNLIIFSPSVEDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGSECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENLLKAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQYPHAVGKNTLLIAGLQARNNARVIFSGSLDFFSDSFFNSAVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPNAYTVTDLVEYSIVIQQLSNGKWVPFDGDDIQLEFVRIDPFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPLQHTQYERFIPSAYPYYASAFSMMLGLFIFSIVFLHMKEKEKSD
  
Inhibitor
Name:
BDBM50085484
Synonyms:
2-Benzylamino-5-(4-methoxy-benzylamino)-pentanoic acid ({1-[1-(1-carbamoyl-2-hydroxy-propylcarbamoyl)-2-methyl-propylcarbamoyl]-2-hydroxy-propylcarbamoyl}-methyl)-amide | CHEMBL2370266
Type:
Small organic molecule
Emp. Form.:
C35H53N7O8
Mol. Mass.:
699.8374
SMILES:
COc1ccc(CNCCC[C@H](NCc2ccccc2)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)cc1 |r|
Structure:
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