Reaction Details Report a problem with these data
Target
Protein Tat
Ligand
BDBM50097337
Substrate
n/a
Meas. Tech.
ChEBML_209906
IC50
28±n/a nM
Citation
 Hamasaki, K; Ueno, A Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators. Bioorg Med Chem Lett 11:591-4 (2001) [PubMed]  Article 
Target
Name:
Protein Tat
Synonyms:
Human immunodeficiency virus type 1 Tat protein | Protein Tat | TAT_HV112 | Transactivating regulatory protein | tat
Type:
PROTEIN
Mol. Mass.:
9771.75
Organism:
Human immunodeficiency virus type 1 (isolate PCV12 group M subtype B)(HIV-1)
Description:
ChEMBL_199318
Residue:
86
Sequence:
MEPVDPRLEPWKHPGSQPKTACTNCYCKKCCFHCQVCFITKALGISYGRKKRRQRRRAPQGSQTHQVSLSKQPTSQSRGDPTGPKE
  
Inhibitor
Name:
BDBM50097337
Synonyms:
CHEMBL349996 | Neamine derivative
Type:
Small organic molecule
Emp. Form.:
C35H46N8O8
Mol. Mass.:
706.7885
SMILES:
NC1CC(N)C(OC2OC(CNC(=O)C(CCCNC(N)=N)NC(=O)c3ccc4ccc5cccc6ccc3c4c56)C(O)C(O)C2N)C(O)C1O
Structure:
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