Reaction Details Report a problem with these data
Target
Protein Tat
Ligand
BDBM8580
Substrate
n/a
Meas. Tech.
ChEBML_209906
IC50
28000±n/a nM
Citation
 Hamasaki, K; Ueno, A Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators. Bioorg Med Chem Lett 11:591-4 (2001) [PubMed]  Article 
Target
Name:
Protein Tat
Synonyms:
Human immunodeficiency virus type 1 Tat protein | Protein Tat | TAT_HV112 | Transactivating regulatory protein | tat
Type:
PROTEIN
Mol. Mass.:
9771.75
Organism:
Human immunodeficiency virus type 1 (isolate PCV12 group M subtype B)(HIV-1)
Description:
ChEMBL_199318
Residue:
86
Sequence:
MEPVDPRLEPWKHPGSQPKTACTNCYCKKCCFHCQVCFITKALGISYGRKKRRQRRRAPQGSQTHQVSLSKQPTSQSRGDPTGPKE
  
Inhibitor
Name:
BDBM8580
Synonyms:
(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}oxane-3,4-diol | Neamine
Type:
Small organic molecule
Emp. Form.:
C12H26N4O6
Mol. Mass.:
322.358
SMILES:
NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O |r|
Structure:
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