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Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50130012
Substrate
n/a
Meas. Tech.
ChEBML_105860
IC50
>10000±n/a nM
Citation
 Fotsch, C; Smith, DM; Adams, JA; Cheetham, J; Croghan, M; Doherty, EM; Hale, C; Jarosinski, MA; Kelly, MG; Norman, MH; Tamayo, NA; Xi, N; Baumgartner, JW Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH(2). Bioorg Med Chem Lett 13:2337-40 (2003) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MSHR_MOUSE | Mc1r | Melanocortin receptor 1 | Melanocyte-stimulating hormone receptor | Msh-r
Type:
PROTEIN
Mol. Mass.:
35238.60
Organism:
Mus musculus
Description:
ChEMBL_1498846
Residue:
315
Sequence:
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
  
Inhibitor
Name:
BDBM50130012
Synonyms:
CHEMBL75185 | N-{4-[Acetyl-(4-guanidino-butyl)-amino]-cyclohexyl}-N-[2-(1H-indol-3-yl)-ethyl]-acetamide
Type:
Small organic molecule
Emp. Form.:
C25H38N6O2
Mol. Mass.:
454.6082
SMILES:
CC(=O)N(CCCCNC(N)=N)C1CCC(CC1)N(CCc1c[nH]c2ccccc12)C(C)=O |(14.36,-.97,;13.01,-.22,;13,1.32,;11.7,-1,;10.35,-.24,;10.33,1.3,;9,2.05,;8.97,3.6,;7.63,4.36,;6.31,3.57,;4.96,4.33,;6.33,2.03,;11.7,-2.55,;10.93,-3.9,;9.22,-3.28,;8.04,-3.7,;8.8,-2.34,;10.44,-2.97,;6.71,-2.93,;5.38,-3.7,;5.37,-5.24,;4.02,-6.01,;2.62,-5.37,;1.59,-6.51,;2.36,-7.85,;1.88,-9.3,;2.89,-10.44,;4.4,-10.13,;4.88,-8.67,;3.86,-7.54,;6.71,-1.39,;5.38,-.61,;8.04,-.61,)|
Structure:
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