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Target
Dihydrofolate reductase
Ligand
BDBM50130951
Substrate
n/a
Meas. Tech.
ChEMBL_54391 (CHEMBL668775)
IC50
620±n/a nM
Citation
 Zolli-Juran, M; Cechetto, JD; Hartlen, R; Daigle, DM; Brown, ED High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate. Bioorg Med Chem Lett 13:2493-6 (2003) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
Dihydrofolate reductase (F31V) | dfrA17
Type:
n/a
Mol. Mass.:
17532.46
Organism:
Escherichia coli
Description:
n/a
Residue:
157
Sequence:
MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYAVVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHVEVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
  
Inhibitor
Name:
BDBM50130951
Synonyms:
CHEMBL85364 | N-(4-chloro-2-cyanophenyl)imidodicarbonimidic diamide
Type:
Small organic molecule
Emp. Form.:
C9H9ClN6
Mol. Mass.:
236.661
SMILES:
NC(=N)N=C(N)Nc1ccc(Cl)cc1C#N |w:3.2|
Structure:
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