Reaction Details
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CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
Ligand
BDBM50310540
Substrate
n/a
Meas. Tech.
ChEMBL_216151 (CHEMBL817034)
Ki
65000±n/a nM
Citation
Whalen, LJ; McEvoy, KA; Halcomb, RL Synthesis and evaluation of phosphoramidate amino acid-based inhibitors of sialyltransferases. Bioorg Med Chem Lett 13:301-4 (2002) [PubMed] Article More Info.:
Target
Name:
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
Synonyms:
SIAT6_RAT | Siat6 | St3gal3
Type:
PROTEIN
Mol. Mass.:
42091.50
Organism:
Rattus norvegicus
Description:
ChEMBL_649270
Residue:
374
Sequence:
MGLLVFVRNLLLALCLFLVLGFLYYSAWKLHLLQWEDSNSLILSLDSAGQTLGTEYDRLGFLLKLDSKLPAELATKYANFSEGACKPGYASAMMTAIFPRFSKPAPMFLDDSFRKWARIREFVPPFGIKGQDNLIKAILSVTKEYRLTPALDSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALDGCDEVAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKLVKARVITDLSSGI
Inhibitor
Name:
BDBM50310540
Synonyms:
((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methyl dihydrogen phosphate | ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate | CHEMBL307679 | CYTIDINE-5'-MONOPHOSPHATE | Phosphoric acid mono-[5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester | cytidine 5'-phosphate
Type:
Small organic molecule
Emp. Form.:
C9H14N3O8P
Mol. Mass.:
323.1965
SMILES:
Nc1ccn([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)n1 |r|
Structure:
