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Target
Adrenocorticotropic hormone receptor
Ligand
BDBM50134486
Substrate
n/a
Meas. Tech.
ChEBML_105991
EC50
>10000±n/a nM
Citation
 Dyck, B; Parker, J; Phillips, T; Carter, L; Murphy, B; Summers, R; Hermann, J; Baker, T; Cismowski, M; Saunders, J; Goodfellow, V Aryl piperazine melanocortin MC4 receptor agonists. Bioorg Med Chem Lett 13:3793-6 (2003) [PubMed]  Article 
Target
Name:
Adrenocorticotropic hormone receptor
Synonyms:
ACTHR_MOUSE | Acthr | Mc2r | Melanocortin receptor 2
Type:
PROTEIN
Mol. Mass.:
33990.01
Organism:
Mus musculus
Description:
ChEMBL_105991
Residue:
296
Sequence:
MKHIINSYEHTNDTARNNSDCPDVVLPEEIFFTISVIGILENLIVLLAVIKNKNLQSPMYFFICSLAISDMLGSLYKILENILIMFRNMGYLKPRGSFESTADDIIDCMFILSLLGSIFSLSVIAADRYITIFHALQYHSIVTMRRTIITLTIIWMFCTGSGITMVIFSHHIPTVLTFTSLFPLMLVFILCLYIHMFLLARSHARKISTLPRTNMKGAMTLTILLGVFIFCWAPFVLHVLLMTFCPNNPYCVCYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKRMLFCNRY
  
Inhibitor
Name:
BDBM50134486
Synonyms:
(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-oxo-2-[4-(2-[1,2,4]triazol-1-ylmethyl-phenyl)-piperazin-1-yl]-ethyl}-amide | (R)-N-((R)-1-(4-(2-((1H-1,2,4-triazol-1-yl)methyl)phenyl)piperazin-1-yl)-3-(4-chlorophenyl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | 1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-oxo-2-[4-(2-[1,2,4]triazol-1-ylmethyl-phenyl)-piperazin-1-yl]-ethyl}-amide | CHEMBL340355
Type:
Small organic molecule
Emp. Form.:
C32H34ClN7O2
Mol. Mass.:
584.111
SMILES:
Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCN(CC2)c2ccccc2Cn2cncn2)cc1 |r|
Structure:
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