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Target
Adrenocorticotropic hormone receptor
Ligand
BDBM50119368
Substrate
n/a
Meas. Tech.
ChEBML_105991
EC50
>10000±n/a nM
Citation
 Dyck, B; Parker, J; Phillips, T; Carter, L; Murphy, B; Summers, R; Hermann, J; Baker, T; Cismowski, M; Saunders, J; Goodfellow, V Aryl piperazine melanocortin MC4 receptor agonists. Bioorg Med Chem Lett 13:3793-6 (2003) [PubMed]  Article 
Target
Name:
Adrenocorticotropic hormone receptor
Synonyms:
ACTHR_MOUSE | Acthr | Mc2r | Melanocortin receptor 2
Type:
PROTEIN
Mol. Mass.:
33990.01
Organism:
Mus musculus
Description:
ChEMBL_105991
Residue:
296
Sequence:
MKHIINSYEHTNDTARNNSDCPDVVLPEEIFFTISVIGILENLIVLLAVIKNKNLQSPMYFFICSLAISDMLGSLYKILENILIMFRNMGYLKPRGSFESTADDIIDCMFILSLLGSIFSLSVIAADRYITIFHALQYHSIVTMRRTIITLTIIWMFCTGSGITMVIFSHHIPTVLTFTSLFPLMLVFILCLYIHMFLLARSHARKISTLPRTNMKGAMTLTILLGVFIFCWAPFVLHVLLMTFCPNNPYCVCYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKRMLFCNRY
  
Inhibitor
Name:
BDBM50119368
Synonyms:
(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide | (R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(3H-[1,2,4]triazol-1-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide | (R)-N-((R)-1-(4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpiperidin-1-yl)-3-(4-chlorophenyl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | 1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide | 1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide | CHEMBL339053 | THIQ
Type:
Small organic molecule
Emp. Form.:
C33H41ClN6O2
Mol. Mass.:
589.171
SMILES:
Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(Cn3cncn3)(CC2)C2CCCCC2)cc1
Structure:
Search PDB for entries with ligand similarity: