Reaction Details Report a problem with these data
Target
T-cell surface glycoprotein CD4
Ligand
BDBM50123450
Substrate
n/a
Meas. Tech.
ChEBML_39920
IC50
130±n/a nM
Citation
 Hegde, VR; Puar, MS; Dai, P; Patel, M; Gullo, VP; Chan, TM; Silver, J; Pramanik, BN; Jenh, CH Condensed aromatic peptide family of microbial metabolites, inhibitors of CD28-CD80 interactions. Bioorg Med Chem Lett 13:573-5 (2003) [PubMed]  Article 
Target
Name:
T-cell surface glycoprotein CD4
Synonyms:
CD4 | CD4_HUMAN | CD_antigen=CD4 | T-cell surface antigen CD4 | T-cell surface antigen T4/Leu-3 | T-cell surface glycoprotein CD4
Type:
PROTEIN
Mol. Mass.:
51136.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_440402
Residue:
458
Sequence:
MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI
  
Inhibitor
Name:
BDBM50123450
Synonyms:
CHEMBL3143464 | Chloropeptin I analogue
Type:
Small organic molecule
Emp. Form.:
C64H51Cl6N7O16
Mol. Mass.:
1386.845
SMILES:
CN1[C@@H](Cc2ccc(Oc3cc4cc(c3O)-c3ccc5c(C[C@@H](NC(=O)C(O)(CC(C)=O)c6cc(Cl)c(O)c(Cl)c6)C(=O)N[C@H](c6cc(Cl)c(O)c(Cl)c6)C(=O)N[C@H]4C(=O)N[C@H](c4cc(Cl)c(O)c(Cl)c4)C1=O)c[nH]c5c3)cc2)C(=O)N[C@@H](C(O)=O)c1ccc(O)cc1 |r|
Structure:
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