Reaction Details Report a problem with these data
Target
Glutathione hydrolase 1 proenzyme
Ligand
BDBM50142500
Substrate
n/a
Meas. Tech.
ChEBML_68880
pH
8±n/a
Ki
26900000±n/a nM
Comments
extracted
Citation
 Lherbet, C; Gravel, C; Keillor, JW Synthesis of S-alkyl L-homocysteine analogues of glutathione and their kinetic studies with gamma-glutamyl transpeptidase. Bioorg Med Chem Lett 14:3451-5 (2004) [PubMed]  Article 
Target
Name:
Glutathione hydrolase 1 proenzyme
Synonyms:
GGT1_RAT | Gamma-glutamyltranspeptidase 1 | Ggt | Ggt1
Type:
PROTEIN
Mol. Mass.:
61615.37
Organism:
Rattus norvegicus
Description:
ChEMBL_68879
Residue:
568
Sequence:
MKNRFLVLGLVAVVLVFVIIGLCIWLPTTSGKPDHVYSRAAVATDAKRCSEIGRDMLQEGGSVVDAAIASLLCMGLINAHSMGIGGGLFFTIYNSTTRKAEVINAREMAPRLANTSMFNNSKDSEEGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARHGFPVGKGLARALDKKRDIIEKTPALCEVFCRQGKVLQEGETVTMPKLADTLQILAQEGARAFYNGSLTAQIVKDIQEAGGIMTVEDLNNYRAEVIEHPMSIGLGDSTLYVPSAPLSGPVLILILNILKGYNFSPKSVATPEQKALTYHRIVEAFRFAYAKRTMLGDPKFVDVSQVIRNMSSEFYATQLRARITDETTHPTAYYEPEFYLPDDGGTAHLSVVSEDGSAVAATSTINLYFGSKVLSRVSGILFNDEMDDFSSPNFTNQFGVAPSPANFIKPGKQPLSSMCPSIIVDKDGKVRMVVGASGGTQITTSVALAIINSLWFGYDVKRAVEEPRLHNQLLPNTTTVEKNIDQVVTAGLKTRHHHTEVTPDFIAVVQAVVRTSGGWAAASDSRKGGEPAGY
  
Inhibitor
Name:
BDBM50142500
Synonyms:
(2S)-2-amino-4-(methylsulfanyl)butanoic acid | (S)-2-amino-4-(methylthio)butanoic acid | (S)-2-amino-4-(methylthio)butyric acid | (S)-methionine | CHEMBL42336 | L-(-)-methionine | L-Methionin | L-alpha-amino-gamma-methylmercaptobutyric acid | L-methionine | US11021454, Compound L-met
Type:
Small organic molecule
Emp. Form.:
C5H11NO2S
Mol. Mass.:
149.211
SMILES:
CSCC[C@H](N)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: