Reaction Details Report a problem with these data
Target
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5
Ligand
BDBM50366925
Substrate
n/a
Meas. Tech.
ChEMBL_69142 (CHEMBL681266)
Ki
889000±n/a nM
Citation
 Norris, AJ; Whitelegge, JP; Strouse, MJ; Faull, KF; Toyokuni, T Inhibition kinetics of carba- and C-fucosyl analogues of GDP-fucose against fucosyltransferase V: implication for the reaction mechanism. Bioorg Med Chem Lett 14:571-3 (2004) [PubMed]  Article 
Target
Name:
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5
Synonyms:
FUT5 | FUT5_HUMAN | Fucosyltransferase 5
Type:
PROTEIN
Mol. Mass.:
43016.71
Organism:
Homo sapiens (Human)
Description:
ChEMBL_69264
Residue:
374
Sequence:
MDPLGPAKPQWLWRRCLAGLLFQLLVAVCFFSYLRVSRDDATGSPRPGLMAVEPVTGAPNGSRCQDSMATPAHPTLLILLWTWPFNTPVALPRCSEMVPGAADCNITADSSVYPQADAVIVHHWDIMYNPSANLPPPTRPQGQRWIWFSMESPSNCRHLEALDGYFNLTMSYRSDSDIFTPYGWLEPWSGQPAHPPLNLSAKTELVAWAVSNWKPDSARVRYYQSLQAHLKVDVYGRSHKPLPKGTMMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPPDAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALAFCKACWKLQQESRYQTVRSIAAWFT
  
Inhibitor
Name:
BDBM50366925
Synonyms:
CHEMBL610712
Type:
Small organic molecule
Emp. Form.:
C17H27N5O14P2
Mol. Mass.:
587.3689
SMILES:
CC1OC(CP(O)(=O)OP(O)(=O)OC[C@H]2OC([C@H](O)[C@@H]2O)n2cnc3c2nc(N)[nH]c3=O)C(O)C(O)C1O |r|
Structure:
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