Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM50144577
Substrate
n/a
Meas. Tech.
ChEBML_212190
IC50
240±n/a nM
Citation
 Sutton, JC; Bolton, SA; Davis, ME; Hartl, KS; Jacobson, B; Mathur, A; Ogletree, ML; Slusarchyk, WA; Zahler, R; Seiler, SM; Bisacchi, GS Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. Bioorg Med Chem Lett 14:2233-9 (2004) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I
Type:
Enzyme
Mol. Mass.:
25790.52
Organism:
Bos taurus (bovine)
Description:
P00760
Residue:
246
Sequence:
MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN
  
Inhibitor
Name:
BDBM50144577
Synonyms:
(R)-1-[4-(6-Naphthalen-1-yl-hexanoyl)-piperazine-1-carbonyl]-4-oxo-3-piperidin-4-ylmethyl-azetidine-2-carboxylic acid | CHEMBL72532
Type:
Small organic molecule
Emp. Form.:
C31H40N4O5
Mol. Mass.:
548.6731
SMILES:
OC(=O)[C@@H]1[C@@H](CC2CCNCC2)C(=O)N1C(=O)N1CCN(CC1)C(=O)CCCCCc1cccc2ccccc12
Structure:
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