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Target
Pyruvate kinase PKLR
Ligand
BDBM50028624
Substrate
n/a
Meas. Tech.
ChEMBL_160251 (CHEMBL767865)
Ki
2200000±n/a nM
Citation
 Hai, TT; Abo, M; Hampton, A Species- or isozyme-specific enzyme inhibitors. 9. Selective effects in inhibitions of rat pyruvate kinase isozymes by adenosine 5'-diphosphate derivatives. J Med Chem 25:1184-8 (1983) [PubMed]  Article 
Target
Name:
Pyruvate kinase PKLR
Synonyms:
KPYR_RAT | Pklr | Pyruvate kinase isozymes R/L
Type:
PROTEIN
Mol. Mass.:
62202.26
Organism:
Rattus norvegicus
Description:
ChEMBL_1359662
Residue:
574
Sequence:
MSVQENTLPQQLWPWIFRSQKDLAKSALSGAPGGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSQPVAARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFATSPLSYRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFQTRGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSRKGVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGPEGQNIKIISKIENHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSVS
  
Inhibitor
Name:
BDBM50028624
Synonyms:
CHEMBL3142978 | [6-(6-amino-9H-purin-9-yl)-2-methyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]methyl trihydrogen diphosphate
Type:
Small organic molecule
Emp. Form.:
C12H17N5O10P2
Mol. Mass.:
453.2384
SMILES:
CC1O[C@@H]2[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]2O1)n1cnc2c(N)ncnc12 |r|
Structure:
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