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Target
Pyruvate kinase PKM
Ligand
BDBM50028625
Substrate
n/a
Meas. Tech.
ChEBML_160380
Ki
9300000±n/a nM
Citation
 Hai, TT; Abo, M; Hampton, A Species- or isozyme-specific enzyme inhibitors. 9. Selective effects in inhibitions of rat pyruvate kinase isozymes by adenosine 5'-diphosphate derivatives. J Med Chem 25:1184-8 (1983) [PubMed]  Article 
Target
Name:
Pyruvate kinase PKM
Synonyms:
KPYM_RAT | Pkm | Pkm2 | Pykm | Pyruvate kinase isozymes M1/M2
Type:
PROTEIN
Mol. Mass.:
57820.70
Organism:
Rattus norvegicus
Description:
ChEMBL_160255
Residue:
531
Sequence:
MPKPDSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRAATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAVFHRLLFEELARASSQSTDPLEAMAMGSVEASYKCLAAALIVLTESGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLDAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
  
Inhibitor
Name:
BDBM50028625
Synonyms:
CHEMBL3142968 | [5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl]methyl trihydrogen diphosphate
Type:
Small organic molecule
Emp. Form.:
C11H17N5O10P2
Mol. Mass.:
441.2277
SMILES:
CO[C@@H]1[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c(N)ncnc12 |r|
Structure:
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