Reaction Details Report a problem with these data
Target
Phenylethanolamine N-methyltransferase
Ligand
BDBM50023171
Substrate
n/a
Meas. Tech.
ChEBML_142787
Ki
460000±n/a nM
Citation
 Grunewald, GL; Monn, JA; Rafferty, MF; Borchardt, RT; Krass, P Probes of the active site of norepinephrine N-methyltransferase: effect of hydrophobic and hydrophilic interactions on side-chain binding of amphetamine and alpha-methylbenzylamine. J Med Chem 25:1248-50 (1983) [PubMed]  Article 
Target
Name:
Phenylethanolamine N-methyltransferase
Synonyms:
Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase
Type:
Enzyme
Mol. Mass.:
30916.97
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
283
Sequence:
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGAFDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVREALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
  
Inhibitor
Name:
BDBM50023171
Synonyms:
1-amino-1-phenylethane | 1-phenethylamine | 1-phenylethanamine | 1-phenylethylamine | CHEMBL278059 | alpha-Methylbenzylamine | alpha-Phenylethylamine | alpha-aminoethylbenzene | alpha-methylbenzenemethanamine
Type:
Small organic molecule
Emp. Form.:
C8H11N
Mol. Mass.:
121.1796
SMILES:
CC(N)c1ccccc1
Structure:
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