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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50021224
Substrate
n/a
Meas. Tech.
ChEMBL_176345 (CHEMBL783267)
IC50
1700±n/a nM
Citation
 Bøgesø, KP; Christensen, AV; Hyttel, J; Liljefors, T 3-Phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of dopamine, norepinephrine, and serotonin uptake. J Med Chem 28:1817-28 (1986) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50021224
Synonyms:
(+) (trans) 1-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-4-methyl-piperazine; Dihydrochloride | (+)(cis) 1-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-4-methyl-piperazine; Dihydrochloride | (-) (trans) 1-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-4-methyl-piperazine; Dihydrochloride | (-)(cis) 1-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-4-methyl-piperazine; Dihydrochloride | (cis) 1-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-4-methyl-piperazine; Dihydrochloride | (trans) 1-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-4-methyl-piperazine; Dihydrochloride | 1-[3-(3,4-Dichloro-phenyl)-indan-1-yl]-4-methyl-piperazine | CHEMBL54177
Type:
Small organic molecule
Emp. Form.:
C20H22Cl2N2
Mol. Mass.:
361.308
SMILES:
CN1CCN(CC1)C1CC(c2ccccc12)c1ccc(Cl)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: