Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50004571
Substrate
n/a
Meas. Tech.
ChEMBL_28532 (CHEMBL640700)
IC50
270±n/a nM
Citation
 Sarges, R; Howard, HR; Browne, RG; Lebel, LA; Seymour, PA; Koe, BK 4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants. J Med Chem 33:2240-54 (1990) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1
Type:
Protein
Mol. Mass.:
36704.13
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
326
Sequence:
MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
  
Inhibitor
Name:
BDBM50004571
Synonyms:
8-Chloro-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-ylamine | CHEMBL303198 | CP-66713
Type:
Small organic molecule
Emp. Form.:
C15H10ClN5
Mol. Mass.:
295.726
SMILES:
Nc1nc2ccc(Cl)cc2n2c(nnc12)-c1ccccc1
Structure:
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