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Target
Inositol polyphosphate-5-phosphatase A
Ligand
BDBM50075183
Substrate
n/a
Meas. Tech.
ChEMBL_4316 (CHEMBL618424)
Ki
15000±n/a nM
Citation
 Kozikowski, AP; Ognyanov, VI; Chen, C; Fauq, AH; Safrany, ST; Wilcox, RA; Nahorski, SR Deoxygenated inositol 1,4,5-trisphosphate analogues and their interaction with metabolic enzymes. (1R,2R,4R)-cyclohexane-1,2,4-tris(methylenesulfonate): a potent selective 5-phosphatase inhibitor. J Med Chem 36:3035-8 (1993) [PubMed]  Article 
Target
Name:
Inositol polyphosphate-5-phosphatase A
Synonyms:
5PTASE | I5P1_HUMAN | INPP5A | Type I inositol-1,4,5-trisphosphate 5-phosphatase
Type:
PROTEIN
Mol. Mass.:
47823.52
Organism:
Homo sapiens (Human)
Description:
ChEMBL_4316
Residue:
412
Sequence:
MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQFDFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDLVNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSKSVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGTALLEFDKELSVFKDRLYELDISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKELVLRSESEEKVVTYDHIGPNVCMGDHKPVFLAFRIMPGAGKPHAHVHKCCVVQ
  
Inhibitor
Name:
BDBM50075183
Synonyms:
1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate | 1D-myo-inositol 1,4,5-tris(dihydrogen phosphate) | 1D-myo-inositol 1,4,5-trisphosphate | 3,5,6-trioxyphosphate-1,2,4-cyclohexanetriol | CHEMBL279107 | D-myo-inositol 1,4,5-trisphosphate | IP3 | InsP3
Type:
Small organic molecule
Emp. Form.:
C6H15O15P3
Mol. Mass.:
420.0956
SMILES:
O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O
Structure:
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