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Target
Glyceraldehyde-3-phosphate dehydrogenase
Ligand
BDBM50422031
Substrate
n/a
Meas. Tech.
ChEMBL_72902 (CHEMBL684096)
IC50
10000±n/a nM
Citation
 Verlinde, CL; Callens, M; Van Calenbergh, S; Van Aerschot, A; Herdewijn, P; Hannaert, V; Michels, PA; Opperdoes, FR; Hol, WG Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness. J Med Chem 37:3605-13 (1994) [PubMed]  Article 
Target
Name:
Glyceraldehyde-3-phosphate dehydrogenase
Synonyms:
G3P_HUMAN | GAPD | GAPDH | Glyceraldehyde-3-phosphate dehydrogenase liver
Type:
PROTEIN
Mol. Mass.:
36060.86
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1511315
Residue:
335
Sequence:
MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE
  
Inhibitor
Name:
BDBM50422031
Synonyms:
8-Phenyladenosine | CHEMBL1775010
Type:
Small organic molecule
Emp. Form.:
C16H17N5O4
Mol. Mass.:
343.3373
SMILES:
Nc1ncnc2n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c(nc12)-c1ccccc1 |r|
Structure:
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