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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM50037933
Substrate
n/a
Meas. Tech.
ChEMBL_202882 (CHEMBL810000)
IC50
147±n/a nM
Citation
 Bakshi, RK; Patel, GF; Rasmusson, GH; Baginsky, WF; Cimis, G; Ellsworth, K; Chang, B; Bull, H; Tolman, RL; Harris, GS 4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase. J Med Chem 37:3871-4 (1994) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50037933
Synonyms:
(4aR,6aR,10R)-7-(1,5-Dimethyl-hexyl)-1,4a,6a,10-tetramethyl-1,3,4,4a,4b,5,6,6a,7,8,9,9a,9b,10-tetradecahydro-indeno[5,4-f]quinolin-2-one | CHEMBL421627
Type:
Small organic molecule
Emp. Form.:
C28H47NO
Mol. Mass.:
413.6789
SMILES:
CC(C)CCCC(C)C1CCC2C3[C@@H](C)C=C4N(C)C(=O)CC[C@]4(C)C3CC[C@]12C |t:15|
Structure:
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