Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM50031491
Substrate
n/a
Meas. Tech.
ChEMBL_35254 (CHEMBL647575)
IC50
0.30±n/a nM
Citation
 Wexler, RR; Greenlee, WJ; Irvin, JD; Goldberg, MR; Prendergast, K; Smith, RD; Timmermans, PB Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. J Med Chem 39:625-56 (1996) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM50031491
Synonyms:
2-propyl-4-(methythio)-1-[[[2'-[(propylamino)carbonyl]amino]sulfonyl](1,1'-biphenyl)-4yl]methyl]-1H-imidazole-5-carboxylic acid | 3-(2'-Propylaminocarbonylsulfamoyl-biphenyl-4-ylmethyl)-5-methylsulfanyl-2-propyl-3H-imidazole-4-carboxylic acid | 3-(N'-propylureidylsulfonyl-biphenyl-4-ylmethyl)-5-methylsulfanyl-2-propyl-3H-imidazole-4-carboxylic acid(S0029) | CHEMBL63998
Type:
Small organic molecule
Emp. Form.:
C25H30N4O5S2
Mol. Mass.:
530.66
SMILES:
CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: