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Target
Thyrotropin-releasing hormone receptor
Ligand
BDBM50050532
Substrate
n/a
Meas. Tech.
ChEMBL_207855 (CHEMBL810063)
Ki
1500±n/a nM
Citation
 Rutledge, LD; Perlman, JH; Gershengorn, MC; Marshall, GR; Moeller, KD Conformationally restricted TRH analogs: a probe for the pyroglutamate region. J Med Chem 39:1571-4 (1996) [PubMed]  Article 
Target
Name:
Thyrotropin-releasing hormone receptor
Synonyms:
TRH-R | TRHR_MOUSE | Thyroliberin receptor | Trhr | thyrotropin-releasing hormone R1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44568.52
Organism:
MOUSE
Description:
thyrotropin-releasing hormone R1 TRHR MOUSE::P21761
Residue:
393
Sequence:
MENDTVSEMNQTELQPQAAVALEYQVVTILLVVIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKNAVVVSCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKMWKNDSIHQNKNLNLNATNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELEDITVTDTYVSTTKVSFDDTCLASEN
  
Inhibitor
Name:
BDBM50050532
Synonyms:
1-[2-[2-oxo-(5S)-dihydro-2H-5-pyrrolylcarboxamido]-3-phenyl-(2S)-propanoyl]-(2S)-tetrahydro-1H-2-pyrrolecarboxamide | CHEMBL36631
Type:
Small organic molecule
Emp. Form.:
C19H24N4O4
Mol. Mass.:
372.4183
SMILES:
NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)N1
Structure:
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