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Target
Muscarinic acetylcholine receptor M3
Ligand
BDBM50034625
Substrate
n/a
Meas. Tech.
ChEMBL_138834 (CHEMBL753022)
EC50
10000±n/a nM
Citation
 Messer, WS; Abuh, YF; Liu, Y; Periyasamy, S; Ngur, DO; Edgar, MA; El-Assadi, AA; Sbeih, S; Dunbar, PG; Roknich, S; Rho, T; Fang, Z; Ojo, B; Zhang, H; Huzl, JJ; Nagy, PI Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists. J Med Chem 40:1230-46 (1997) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M3
Synonyms:
ACM3_MOUSE | Chrm-3 | Chrm3 | Mm3 mAChR | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M3
Type:
PROTEIN
Mol. Mass.:
66232.94
Organism:
Mus musculus
Description:
ChEMBL_138834
Residue:
589
Sequence:
MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVSQLDSYNISQTSGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGTKRSSRRKYGGCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPDKDLGTMDVERNAHKLQAQKSMDDRDNCQKDFSKLPIQLESAVDTAKTSDTNSSVDKTTAALPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
  
Inhibitor
Name:
BDBM50034625
Synonyms:
Aceclidine | Acetic acid 1-aza-bicyclo[2.2.2]oct-3-yl ester | Acetic acid 1-aza-bicyclo[2.2.2]oct-3-yl ester(aceclidine) | CHEMBL20835 | aceclidine,R(-) | aceclidine,S(+)
Type:
Small organic molecule
Emp. Form.:
C9H15NO2
Mol. Mass.:
169.2209
SMILES:
CC(=O)OC1CN2CCC1CC2 |(10.76,-5.27,;9.32,-4.51,;9.32,-2.9,;7.94,-5.34,;6.53,-4.61,;6.53,-3.08,;5.18,-2.29,;4.35,-3.24,;4.35,-4.51,;5.2,-5.39,;3.85,-4.62,;3.85,-3.08,)|
Structure:
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