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Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50366633
Substrate
n/a
Meas. Tech.
ChEMBL_48268 (CHEMBL663173)
IC50
48±n/a nM
Citation
 Trivedi, BK; Padia, JK; Holmes, A; Rose, S; Wright, DS; Hinton, JP; Pritchard, MC; Eden, JM; Kneen, C; Webdale, L; Suman-Chauhan, N; Boden, P; Singh, L; Field, MJ; Hill, D Second generation"peptoid" CCK-B receptor antagonists: identification and development of N-(adamantyloxycarbonyl)-alpha-methyl-(R)-tryptophan derivative (CI-1015) with an improved pharmacokinetic profile. J Med Chem 41:38-45 (1998) [PubMed]  Article 
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
Cckbr | Cholecystokinin A | Cholecystokinin receptor | GASR_MOUSE | Gastrin/cholecystokinin type B receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49196.59
Organism:
MOUSE
Description:
Cholecystokinin A CCKBR MOUSE::P56481
Residue:
453
Sequence:
MDLLKLNRSLQGPGPGSGSSLCRPGVSLLNSSSAGNLSCETPRIRGTGTRELELTIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTVVQPVGPRILQCMHLWPSERVQQMWSVLLLILLFFIPGVVMAVAYGLISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAPGPVHQNGGCRHVTSLTGEDSDGCYVQLPRSRLEMTTLTTPTTGPGPGPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANTWRAFDGPGARRALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDTCARCCPRPPRARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50366633
Synonyms:
CHEMBL1169566
Type:
Small organic molecule
Emp. Form.:
C31H37N3O3
Mol. Mass.:
499.6438
SMILES:
C[C@](Cc1c[nH]c2ccccc12)(NC(=O)OC1C2CC3CC(C2)CC1C3)C(=O)NCCc1ccccc1 |r,wU:1.13,wD:1.0,TLB:15:16:18:20.22.21,22:21:25:18.17.16,22:17:25:20.23.21,THB:23:21:18:25.24.16,23:24:18:20.22.21,15:16:25:20.23.21,(6.03,-6.13,;5.44,-7.56,;4.85,-8.98,;3.32,-9.18,;2.26,-8.06,;.87,-8.72,;1.07,-10.25,;.07,-11.42,;.58,-12.87,;2.1,-13.15,;3.1,-11.98,;2.59,-10.53,;4.02,-6.97,;3.82,-5.44,;5.04,-4.5,;2.32,-4.82,;2.43,-3.02,;1.06,-2.32,;.22,-3.79,;1.59,-3.1,;1.59,-1.7,;2.43,-.23,;1.06,-.92,;3.8,-.92,;3.8,-2.32,;2.96,-3.79,;6.86,-8.15,;8.09,-7.21,;7.06,-9.67,;8.48,-10.27,;8.68,-11.79,;10.11,-12.38,;10.31,-13.91,;11.73,-14.5,;12.95,-13.56,;12.75,-12.04,;11.33,-11.45,)|
Structure:
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