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Target
Dihydroorotate dehydrogenase (quinone), mitochondrial
Ligand
BDBM50066586
Substrate
n/a
Meas. Tech.
ChEMBL_52887 (CHEMBL665411)
IC50
22400±n/a nM
Citation
 Papageorgiou, C; Albert, R; Floersheim, P; Lemaire, M; Bitch, F; Weber, HP; Andersen, E; Hungerford, V; Schreier, MH Pyrazole bioisosteres of leflunomide as B-cell immunosuppressants for xenotransplantation and chronic rejection: scope and limitations. J Med Chem 41:3530-8 (1998) [PubMed]  Article 
Target
Name:
Dihydroorotate dehydrogenase (quinone), mitochondrial
Synonyms:
DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN
Type:
Enzyme
Mol. Mass.:
42881.33
Organism:
Homo sapiens (Human)
Description:
Q02127
Residue:
395
Sequence:
MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
  
Inhibitor
Name:
BDBM50066586
Synonyms:
5-Methyl-3-(2,4,6-trifluoro-phenylamino)-1H-pyrazole-4-carbonitrile | CHEMBL118125
Type:
Small organic molecule
Emp. Form.:
C11H7F3N4
Mol. Mass.:
252.1953
SMILES:
Cc1n[nH]c(Nc2c(F)cc(F)cc2F)c1C#N
Structure:
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