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Target
Sodium- and chloride-dependent GABA transporter 1
Ligand
BDBM50080355
Substrate
n/a
Meas. Tech.
ChEMBL_202725 (CHEMBL807623)
Ki
32±n/a nM
Citation
Knutsen, LJ; Andersen, KE; Lau, J; Lundt, BF; Henry, RF; Morton, HE; Naerum, L; Petersen, H; Stephensen, H; Suzdak, PD; Swedberg, MD; Thomsen, C; Sørensen, PO Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents. J Med Chem 42:3447-62 (1999) [PubMed] Article
More Info.:
Target
Name:
Sodium- and chloride-dependent GABA transporter 1
Synonyms:
GABA transporter | Gabt1 | Gat-1 | Gat1 | SC6A1_RAT | Slc6a1 | Solute carrier family 6 member 1
Type:
PROTEIN
Mol. Mass.:
67006.26
Organism:
Rattus norvegicus
Description:
ChEMBL_1472611
Residue:
599
Sequence:
MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
Inhibitor
Name:
BDBM50080355
Synonyms:
(R)-1-{2-[2,2-Bis-(2-ethyl-phenyl)-vinyloxy]-ethyl}-piperidine-3-carboxylic acid; hydrochloride | CHEMBL545280
Type:
Small organic molecule
Emp. Form.:
C26H33NO3
Mol. Mass.:
407.5451
SMILES:
[#6]-[#6]-c1ccccc1\[#6](=[#6]\[#8]-[#6]-[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6@H](-[#6]-1)-[#6](-[#8])=O)-c1ccccc1-[#6]-[#6]