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Target
B2 bradykinin receptor
Ligand
BDBM50081666
Substrate
n/a
Meas. Tech.
ChEMBL_40426 (CHEMBL652641)
Ki
1030±n/a nM
Citation
 Amblard, M; Daffix, I; Bergé, G; Calmès, M; Dodey, P; Pruneau, D; Paquet, JL; Luccarini, JM; Bélichard, P; Martinez, J Synthesis and characterization of bradykinin B(2) receptor agonists containing constrained dipeptide mimics. J Med Chem 42:4193-201 (1999) [PubMed]  Article 
Target
Name:
B2 bradykinin receptor
Synonyms:
B2 BRADYKININ | B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKR2 | BKRB2_HUMAN | Bradykinin B2 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44467.17
Organism:
Homo sapiens (Human)
Description:
B2 BRADYKININ BDKRB2 HUMAN::P30411
Residue:
391
Sequence:
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ
  
Inhibitor
Name:
BDBM50081666
Synonyms:
(3-(Ser-Thi-Gly-Hyp-Pro-Arg-D-Arg-H),-2-oxo-pyrrolidin-1-yl)-acetyl-(Arg-OH) | CHEMBL436963
Type:
Small organic molecule
Emp. Form.:
C46H75N19O13S
Mol. Mass.:
1134.272
SMILES:
N[C@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CC(O)C[C@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N[C@H]1CCN(CC(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=O
Structure:
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