Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 1
Ligand
BDBM50082729
Substrate
n/a
Meas. Tech.
ChEMBL_41751 (CHEMBL651702)
Ki
9±n/a nM
Citation
 Ng, HP; May, K; Bauman, JG; Ghannam, A; Islam, I; Liang, M; Horuk, R; Hesselgesser, J; Snider, RM; Perez, HD; Morrissey, MM Discovery of novel non-peptide CCR1 receptor antagonists. J Med Chem 42:4680-94 (1999) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 1
Synonyms:
C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1
Type:
Enzyme
Mol. Mass.:
41180.69
Organism:
Homo sapiens (Human)
Description:
P32246
Residue:
355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
  
Inhibitor
Name:
BDBM50082729
Synonyms:
1-{5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentyl}-3-piperidin-4-yl-urea | CHEMBL142752
Type:
Small organic molecule
Emp. Form.:
C34H43ClN4O2
Mol. Mass.:
575.184
SMILES:
OC1(CCN(CCCC(CNC(=O)NC2CCNCC2)(c2ccccc2)c2ccccc2)CC1)c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: