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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50083310
Substrate
n/a
Meas. Tech.
ChEMBL_1432 (CHEMBL616306)
Ki
38±n/a nM
Citation
 Abou-Gharbia, MA; Childers, WE; Fletcher, H; McGaughey, G; Patel, U; Webb, MB; Yardley, J; Andree, T; Boast, C; Kucharik, RJ; Marquis, K; Morris, H; Scerni, R; Moyer, JA Synthesis and SAR of adatanserin: novel adamantyl aryl- and heteroarylpiperazines with dual serotonin 5-HT(1A) and 5-HT(2) activity as potential anxiolytic and antidepressant agents. J Med Chem 42:5077-94 (2000) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50083310
Synonyms:
CHEMBL542752 | N-{2-[4-(3-Chloro-phenyl)-piperazin-1-yl]-ethyl}-2-(3-methyl-adamantan-1-yl)-acetamide; Dihydrochloride
Type:
Small organic molecule
Emp. Form.:
C25H36ClN3O
Mol. Mass.:
430.026
SMILES:
C[C@]12C[C@@H]3C[C@H](C1)CC(CC(=O)NCCN1CCN(CC1)c1cccc(Cl)c1)(C3)C2 |TLB:9:8:6:3.2.4,28:8:6:3.2.4,THB:9:8:2:5.6.4,7:8:2:5.6.4,28:3:8.29.7:6|
Structure:
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