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Target
Kappa-type opioid receptor
Ligand
BDBM50091001
Substrate
n/a
Meas. Tech.
ChEMBL_145508 (CHEMBL752150)
Ki
54±n/a nM
Citation
 Ronsisvalle, G; Pasquinucci, L; Pittalà, V; Marrazzo, A; Prezzavento, O; Di Toro, R; Falcucci, B; Spampinato, S Nonpeptide analogues of dynorphin A(1-8): design, synthesis, and pharmacological evaluation of kappa-selective agonists. J Med Chem 43:2992-3004 (2000) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50091001
Synonyms:
2-[5-Guanidino-2-(5-guanidino-2-{[2-(8-hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2,6-methano-benzo[d]azocin-3-ylmethyl)-1-phenyl-cyclopropanecarbonyl]-amino}-pentanoylamino)-pentanoylamino]-3-methyl-pentanoic acid methyl ester (MPCB-GRRI) | CHEMBL320439
Type:
Small organic molecule
Emp. Form.:
C46H69N11O7
Mol. Mass.:
888.1096
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@]1(CC1CN1CC[C@]2(C)C(C)C1Cc1ccc(O)cc21)c1ccccc1)C(=O)OC |TLB:37:38:43:53.47.46,THB:52:53:43:38.40.39|
Structure:
Search PDB for entries with ligand similarity: