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Target
Cyclin-dependent kinase 5
Ligand
BDBM7580
Substrate
n/a
Meas. Tech.
ChEMBL_51306 (CHEMBL884356)
IC50
300±n/a nM
Citation
 Ducrot, P; Legraverend, M; Grierson, DS 3D-QSAR CoMFA on cyclin-dependent kinase inhibitors. J Med Chem 43:4098-108 (2000) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 5
Synonyms:
CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit
Type:
Enzyme Subunit
Mol. Mass.:
33308.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
292
Sequence:
MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
  
Inhibitor
Name:
BDBM7580
Synonyms:
1-(6-anilino-9-isopropyl-9H-purin-2-yl)-3-methylpent-1-yn-3-ol | 3-methyl-1-[6-(phenylamino)-9-(propan-2-yl)-9H-purin-2-yl]pent-1-yn-3-ol | C-2 alkynylated purine deriv. 5a | CHEMBL284899
Type:
Small organic molecule
Emp. Form.:
C20H23N5O
Mol. Mass.:
349.4295
SMILES:
CCC(C)(O)C#Cc1nc(Nc2ccccc2)c2ncn(C(C)C)c2n1
Structure:
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