Target
Histone deacetylase
Ligand
BDBM50369769
Substrate
n/a
Meas. Tech.
ChEMBL_87390 (CHEMBL691505)
IC50
28±n/a nM
Citation
 Meinke, PTColletti, SLDoss, GMyers, RWGurnett, AMDulski, PMDarkin-Rattray, SJAllocco, JJGaluska, SSchmatz, DMWyvratt, MJFisher, MH Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents. J Med Chem 43:4919-22 (2000) [PubMed]  Article 
Target
Name:
Histone deacetylase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
48692.87
Organism:
Cryptosporidium parvum
Description:
ChEMBL_87390
Residue:
432
Sequence:
MGAKKKIAYFYDEEVGNFHYGLGHPMKPHRVRMTHDLVSQYGLLEKVDVMVPTPGTVESLTRFHSNDYVDFLRSVNTDNMHDYSDHLARFNVGEDCPVFDGLWEFCQLSAGGSLGGAQSVNELGYQYAINWAGGLHHGKKHEASGFCYVNDCVLGALEFLKYQHRVCYVDIDIHHGDGVEEAFYTSPRCMCVSFHKYGDYFPGTGALNDVGVEEGLGYSVNVPLKDGVDDATFIDLFTKVMTLVMENYRPGAIVLQCGADSLSGDRLGCFNLSLKGHGHAVSFLKKFNVPLLILGGGGYTLRNVPKCWTYETSLIVDTYIDEQLPNSSNFYGYYGPDFSLAVRTSNMENLNSRQDCEEIYRKISENFRDYVFPIGSQISAYDIPEKLPLLYNPNKTPDDYKDGNNIKHEQHQDFDDEMKEWPTVDYNNRAIG
  
Inhibitor
Name:
BDBM50369769
Synonyms:
CHEMBL1791140
Type:
Small organic molecule
Emp. Form.:
C36H51N5O6
Mol. Mass.:
649.82
SMILES:
CCCn1cc([C@@H]2NC(=O)[C@H](CCCCCC(=O)CC)NC(=O)[C@H]3CCCCN3C(=O)[C@@H](NC2=O)[C@H](C)CC)c(=O)c2ccccc12
Structure:
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