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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Ligand
BDBM50116422
Substrate
n/a
Meas. Tech.
ChEMBL_205193 (CHEMBL812008)
IC50
1600±n/a nM
Citation
 Picard, F; Barassin, S; Mokhtarian, A; Hartmann, RW Synthesis and evaluation of 2'-substituted 4-(4'-carboxy- or 4'-carboxymethylbenzylidene)-N-acylpiperidines: highly potent and in vivo active steroid 5alpha-reductase type 2 inhibitors. J Med Chem 45:3406-17 (2002) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms:
S5A1_RAT | Srd5a1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1
Type:
PROTEIN
Mol. Mass.:
29788.29
Organism:
Rattus norvegicus
Description:
ChEMBL_1441437
Residue:
259
Sequence:
MVPLMELDELCLLDMLVYLEGFMAFVSIVGLRSVGSPYGRYSPQWPGIRVPARPAWFIQELPSMAWPLYEYIRPAAARLGNLPNRVLLAMFLIHYVQRTLVFPVLIRGGKPTLLVTFVLAFLFCTFNGYVQSRYLSQFAVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGETGYKIPRGGLFEYVSAANYFGELVEWCGFALASWSLQGVVFALFTLSTLLTRAKQHHQWYHEKFEDYPKSRKILIPFVL
  
Inhibitor
Name:
BDBM50116422
Synonyms:
4-[1-(3,3-Diphenyl-propionyl)-piperidin-4-ylidenemethyl]-benzoic acid | CHEMBL117643
Type:
Small organic molecule
Emp. Form.:
C28H27NO3
Mol. Mass.:
425.5189
SMILES:
[#8]-[#6](=O)-c1ccc(\[#6]=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-[#6](-c2ccccc2)-c2ccccc2)cc1
Structure:
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