Reaction Details Report a problem with these data
Target
P2X purinoceptor 2
Ligand
BDBM50118226
Substrate
n/a
Meas. Tech.
ChEMBL_147393 (CHEMBL751802)
EC50
10000±n/a nM
Citation
 Jacobson, KA; Jarvis, MF; Williams, M Purine and pyrimidine (P2) receptors as drug targets. J Med Chem 45:4057-93 (2002) [PubMed]  Article 
Target
Name:
P2X purinoceptor 2
Synonyms:
ATP receptor | P2RX2_RAT | P2X purinoceptor 2 | P2X2 | P2X2/P2X3 receptor | P2rx2 | Purinergic receptor | Purinergic, P2X2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52625.55
Organism:
RAT
Description:
Purinergic, P2X2 0 RAT::P49653
Residue:
472
Sequence:
MVRRLARGCWSAFWDYETPKVIVVRNRRLGFVHRMVQLLILLYFVWYVFIVQKSYQDSETGPESSIITKVKGITMSEDKVWDVEEYVKPPEGGSVVSIITRIEVTPSQTLGTCPESMRVHSSTCHSDDDCIAGQLDMQGNGIRTGHCVPYYHGDSKTCEVSAWCPVEDGTSDNHFLGKMAPNFTILIKNSIHYPKFKFSKGNIASQKSDYLKHCTFDQDSDPYCPIFRLGFIVEKAGENFTELAHKGGVIGVIINWNCDLDLSESECNPKYSFRRLDPKYDPASSGYNFRFAKYYKINGTTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSIGVGSFLCDWILLTFMNKNKLYSHKKFDKVRTPKHPSSRWPVTLALVLGQIPPPPSHYSQDQPPSPPSGEGPTLGEGAELPLAVQSPRPCSISALTEQVVDTLGQHMGQRPPVPEPSQQDSTSTDPKGLAQL
  
Inhibitor
Name:
BDBM50118226
Synonyms:
CHEMBL337062 | PAPET-ATP
Type:
Small organic molecule
Emp. Form.:
C18H25N6O13P3S
Mol. Mass.:
658.41
SMILES:
Nc1ccc(CCSc2nc(N)c3ncn([C@@H]4O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]4O)c3n2)cc1
Structure:
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