Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50111591
Substrate
n/a
Meas. Tech.
ChEMBL_53613 (CHEMBL661843)
IC50
150000±n/a nM
Citation
 McGovern, SL; Caselli, E; Grigorieff, N; Shoichet, BK A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening. J Med Chem 45:1712-22 (2002) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
1.5.1.3 | DHFR | DYR_CHICK
Type:
n/a
Mol. Mass.:
21652.69
Organism:
Gallus gallus (Chicken)
Description:
n/a
Residue:
189
Sequence:
VRSLNSIVAVCQNMGIGKDGNLPWPPLRNEYKYFQRMTSTSHVEGKQNAVIMGKKTWFSIPEKNRPLKDRINIVLSRELKEAPKGAHYLSKSLDDALALLDSPELKSKVDMVWIVGGTAVYKAAMEKPINHRLFVTRILHEFESDTFFPEIDYKDFKLLTEYPGVPADIQEEDGIQYKFEVYQKSVLAQ
  
Inhibitor
Name:
BDBM50111591
Synonyms:
4-[2-(2,4-Difluoro-phenylamino)-thiazol-4-yl]-benzene-1,2-diol | CHEMBL34034
Type:
Small organic molecule
Emp. Form.:
C15H10F2N2O2S
Mol. Mass.:
320.314
SMILES:
Oc1ccc(cc1O)-c1csc(Nc2ccc(F)cc2F)n1
Structure:
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